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zinc finger protein IA1; insulinoma-associated protein 1 (INSM1, IA1)
Function:
- may be associated with the transformation of neuroendocrine cells
Structure: contains 5 C2H2-type Zn+2 fingers
Compartment: nucleus (putative)
Expression:
- not found in any of the normal tissues tested
Pathology:
- expressed in several tumor cell lines of neuroendocrine origin including
a) pheochromocytoma
b) medullary thyroid carcinoma
c) insulinoma
d) pituitary tumor
e) small cell lung carcinoma
General
C2H2 type zinc finger protein
DNA-binding protein
transcription factor (TF)
Properties
SIZE: MW = 53 kD
entity length = 510 aa
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 1-250
MOTIF: proline residue (SEVERAL)
Zn finger C2H2-type
SITE: 267-287
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 295-317
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 367-390
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 438-464
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 469-492
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 600010
UniProt Q01101
Pfam PF00096
Kegg hsa:3642
References
UniProt :accession Q01101