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inositol-1,3,4,5-tetraphosphate-5-phosphatase; inositol polyphosphate 5-phosphatase type II
Function:
- hydrolyzes the Ca+2-mobilizing second messenger IP3; this is a signal-terminating reaction
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Structure:
- belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type 2 family
- contains 1 Rho-GAP domain
Alternative splicing: named isoforms=4
Expression: platelets
Interactions
molecular events
General
phosphomonoesterase
Properties
SIZE: MW = 75 kD
entity length = 635 aa
MOTIF: active site
Database Correlations
OMIM 147264
UniProt P32019
PFAM correlations
Entrez Gene 3633
ENZYME 3.1.3.36
References
- UniProt :accession P32019
- Menniti FS, Oliver KG, Putney JW Jr, Shears SB.
Inositol phosphates and cell signaling: new views of InsP5 and
InsP6.
Trends Biochem Sci. 1993 Feb;18(2):53-6. Review.
PMID: 8387704