inositol

1,2,3,4,5,6-hexahydroxycyclohexane; a member of the vitamin B complex necessary for growth of yeast & mice. Absence from the diet causes alopecia & dermatitis in mice. It occurs in a number of stereo-isomeric forms: cis-, epi-, allo-, neo-, myo-, muco-, chiro-, & scyllo-inositols. The most abundant naturally occurring isomer is myo-inositol (usually meant by 'inositol'). Pharmacokinetics: 1) crosses the blood brain barrier 2) metabolized to glucose Mechanism of action: - inositol competes with phosphoinositides for interaction of Abeta, thus reduces formation o A-beta oligomers (ADOLS)

Specific

inositol phosphate scyllo-inositol; cocositol; quercinitol; 1,3,5/2,4,6-hexahydroxycyclohexane (AZD-103)

General

lipotropic sugar alcohol

Properties

Database Correlations

PUBCHEM cid=892 Kegg map/map00031

References

Stedman's Medical Dictionary 26th ed, Williams & Wilkins, Baltimore, 1995

Component-of

ascorbate/bioflavonoid/choline bitartrate/cobalamin/inositol/nicotinamide/pantothenate/pyridoxine/riboflavin/thiamine choline/inositol cysteine/inositol/methionine/propionate/urea cysteine/inositol/methionine/urea folic acid/inositol garlic/inositol/policosanol inositol/nicotinic acid