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innate immunity

Physiology: mediated by 1) antigen-independent, pattern recognition receptors 2) Toll-like receptors 3) surfactant (SP-A, SP-D) 4) complement 5) defensins Genetics: - genetic variations in TIRAP may influence susceptibility or resistance to invasive pneumococcal disease [2], malaria [3], & tuberculosis [4] - genetic variations in TIRAP influence susceptibility or resistance to bacterial invasion of the blood & define the bacteremia susceptibility locus 1 (BACTS1) [5] Laboratory: - see ARUP consult [1]

General

immunity (immune system)

References

  1. ARUP Consult: Immunodeficiency, Innate System, TLR-Signaling Defects The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/immunodeficiency-tlr-signaling-defects
  2. OMIM :accession 610799
  3. OMIM :accession 611162
  4. OMIM :accession 607948
  5. OMIM :accession 614382