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cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b; p15INK4B; multiple tumor suppressor 2; MTS-2 (CDKN2B, MTS2)

Function: - p15ink4B & related p16ink4 preferentially inhibit CDK4 & CDK6-cyclin complexes [1] - heterodimer of CDKN2B with CDK4 or CDK6 - p15ink4B is an effector of TGF-beta induced cell-cycle arrest, thus may be involved in the same pathway as p27Kip1 [2] Structure: - belongs to the CDKN2 cyclin-dependent kinase inhibitor family - contains 4 ANK repeats Pathology: - defects in CDKN2B are involved in tumor formation Polymorphism: - genetic variations in CDKN2B may underlie susceptibility to uveal melanoma

Interactions

molecular events

Related

multiple tumor suppressor-2 (MTS2) gene; CDKN2B

General

ankyrin repeat domain protein (ANKRD) anti-oncoprotein (tumor suppressor protein) cyclin-dependent kinase inhibitor (CDKI, CDKN) human longevity protein phosphoprotein

Properties

SIZE: entity length = 138 aa MW = 15 kD COMPARTMENT: cytoplasm MOTIF: ankyrin repeat NAME: ankyrin repeat SITE: 13-39 ankyrin repeat NAME: ankyrin repeat SITE: 46-74 ankyrin repeat NAME: ankyrin repeat SITE: 79-108 ankyrin repeat NAME: ankyrin repeat SITE: 112-138 INHIBITS: protein kinase

Database Correlations

OMIM correlations UniProt P42772 Pfam PF00023 Entrez Gene 1030 Kegg hsa:1030

References

  1. Morgan DO. Principles of CDK regulation. Nature. 1995 Mar 9;374(6518):131-4. Review. PMID: 7877684
  2. Cordon-Cardo C. Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia. Am J Pathol. 1995 Sep;147(3):545-60. Review. PMID: 7677168
  3. Entrez Gene :accession 1030
  4. UniProt :accession P42772
  5. NIEHS-SNPs http://egp.gs.washington.edu/data/cdkn2b/

Component-of

molecular complex