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inhibin beta A chain; activin beta-A chain; erythroid differentiation protein; EDF (INHBA)
Function: inhibin A, activin A & activin AB beta subnit
Structure: belongs to the TGF-beta family
Compartment: secreted
Genetics:
- A & B type beta-inhibin encoded by separate genes
General
beta-inhibin or activin beta chain
Properties
SIZE: entity length = 426 aa
MW = 47 kD
MOTIF: signal sequence {1-20}
N-glycosylation site {N165}
cysteine residue {C314}
MODIFICATION: cysteine residue {C322}
cysteine residue {C321}
MODIFICATION: cysteine residue {C391}
cysteine residue {C322}
MODIFICATION: cysteine residue {C314}
cysteine residue {C350}
MODIFICATION: cysteine residue {C423}
cysteine residue {C354}
MODIFICATION: cysteine residue {C425}
cysteine residue {C390}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C391}
MODIFICATION: cysteine residue {C321}
cysteine residue {C423}
MODIFICATION: cysteine residue {C350}
cysteine residue {C425}
MODIFICATION: cysteine residue {C354}
Database Correlations
OMIM 147290
UniProt P08476
PFAM correlations
Entrez Gene 3624
Kegg hsa:3624
References
- UniProt :accession P08476
- Wikipedia; activin entry
http://en.wikipedia.org/wiki/activin
- Matzuk et al
Alpha-inhibin is a tumour-suppressor gene with gonadal
specificity in mice.
Nature 360:313 1992
PMID: 1448148
Component-of
activin AB