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inhibitor of growth protein 5; p28ING5 (ING5)
May play a role in the regulation of transcription through epigenetic modification of chromatin.
Function:
- component of the HBO1 complex
- component of the MOZ/MORF complex
- through chromatin acetylation, may regulate DNA replication & may function as a transcriptional coactivator
- interacts with H3K4me3 & to a lesser extent with H3K4me2
- interacts with EP300 & TP53
Structure:
- the PHD-type Zn+2 finger mediates the binding to H3K4me3
- belongs to the ING family
- contains 1 PHD-type Zn+2 finger
Compartment: nucleus
Alternative splicing: named isoforms=2
General
inhibitor of growth protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 240 aa
MW = 28 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S118}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 186-235
EFFECTOR-BOUND: Zn+2
MOTIF: binding site
SITE: 188-188
FOR-BINDING-OF: Histone H3K4me3
binding site
SITE: 199-199
FOR-BINDING-OF: Histone H3K4me3
binding site
SITE: 203-203
FOR-BINDING-OF: Histone H3K4me3
binding site
SITE: 211-211
FOR-BINDING-OF: Histone H3K4me3
Database Correlations
OMIM 608525
UniProt Q8WYH8
PFAM correlations
Entrez Gene 84289
Kegg hsa:84289
References
UniProt :accession Q8WYH8