inhibitor of growth protein 3 (p47ING3 protein, HSPC301, ING3)

Function: - component of the NuA4 histone acetyltransferase (HAT complex) - HTATTIP/TIP60, EPC1, & ING3 together constitute a minimal HAT complex termed Piccolo NuA4 Structure: - belongs to the ING family - contains 1 PHD-type Zn⁺² finger Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis & thymus Pathology: - defects in ING3 may be a cause of head & neck cancer (squamous cell carcinomas of the head & neck Note: - may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

General

protein subunit zinc finger protein

Properties

SIZE: entity length = 418 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: serine-rich region {313-329} MOTIF: serine residue (SEVERAL) Zn finger PHD-type NAME: Zn finger PHD-type SITE: 360-409 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM correlations UniProt Q9NXR8 Pfam PF00628 Kegg hsa:5455

References

UniProt :accession Q9NXR8