inhibitor of growth protein 1; transforming growth factor beta-1 response element (ING1)

Function: - cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation - implicated as a tumor suppressor gene - interacts with H3K4me3 & to a lesser extent with H3K4me2 - interacts with TP53 Structure: - the PHD-type Zn⁺² finger mediates binding to H3K4me3 - the polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdinsPs), including phosphatidylinositol-5-phosphate (Ptdins(5)P) (putative) - belongs to the ING family - contains 1 PHD-type Zn⁺² finger Compartment: nucleus (probable) Alternative splicing: named isoforms=5 Expression: - isoform 2 - expressed in all normal tissues & cells examined - expressed in all breast cancer & melanoma cell lines examined - isoform 3 - expressed in testis, liver, & kidney - weaklt expressed in colon & brain - not expressed in breast & cultured melanocytes - isoform 4 - highly expressed in testi - weakly expressed in brain - not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines Pathology: - defects in ING1 are a cause of head & neck cancer

General

inhibitor of growth protein zinc finger protein

Properties

SIZE: entity length = 422 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: Zn finger PHD-type NAME: Zn finger PHD-type SITE: 353-402 EFFECTOR-BOUND: Zn+2 MOTIF: binding site SITE: 355-355 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 366-366 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 370-370 FOR-BINDING-OF: Histone H3K4me3 binding site SITE: 378-378 FOR-BINDING-OF: Histone H3K4me3 PBR {405-422}

Database Correlations

OMIM correlations MORBIDMAP 601566 UniProt Q9UK53 PFAM correlations Entrez Gene 3621 Kegg hsa:3621

References

UniProt :accession Q9UK53