influenza virus NS1A-binding protein (NS1-binding protein, NS1-BP, aryl hydrocarbon receptor-associated protein 3, IVNS1ABP, ARA3, FLARA3, KIAA0850, NS1, NS1BP, HSPC068)

Function: - role in cell division & in dynamic organization of actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats - protects cells from cell death induced by actin destabilization - protects neurons from dendritic spines & actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed - activates Erk signaling pathway when overexpressed in cultured cell lines - may be a component of cellular splicing machinery - role in pre-mRNA splicing (putative) - may mediate inhibition of splicing by NS/influenza virus NS1A protein - functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing concentration of AHR available to activate transcription - interacts with NS/Influenza virus NS1A protein & with aryl hydrocarbon receptor (AHR) Structure: - homodimer, through the BTB domain - contains 1 BACK domain (BTB/Kelch associated domain) - contains 1 BTB domain (POZ domain), inhibits AHR signaling induced by IVNS1ABP - contains 6 Kelch repeats Compartment: - cytoplasm, cytoskeleton, nucleus - associated with actin filaments - localization related to nuclear speckle domains which correspond to interchromatin granules & are enriched in factors involved in pre-mRNA splicing - following influenza A virus infection, redistribution from nuclear speckles to a more diffuse distribution in nucleoplasm

Properties

SIZE: MW = 72 kD entity length = 642 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: BTB domain {32-99} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2 BACK {134-233} AHR interaction {164-368} MOTIF: Ser phosphorylation site {S277} kelch repeat {369-415} kelch repeat {416-463} kelch repeat {465-512} kelch repeat {513-559} kelch repeat {560-606} kelch repeat {608-642}

References

UniProt :accession Q9Y6Y0