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influenza A H3N2 virus

Epidemiology: - children under 10 most common victims - 1/3 of adolescents & adults have some cross-reactive antibody to the virus - 160 patients infected in the Midwest (Ohio, Indiana) in 2012 [4] - years with high H3N2 activity tend to see higher flu morbidity & mortality [5] Pathology: - particularly virulent [CDC FluView] Genetics: - carries genes from avian, swine & human viruses Laboratory: - rRT-PCR Swine Flu Panel - influenza virus A serology - influenza virus A H3 Ab in serum - influenza virus A N2 Ab in serum - influenza virus A H3 antigen - influenza virus A H3 RNA - influenza virus identified by culture

Related

swine flu

General

influenza A virus

Properties

KINGDOM: virus GENOME-TYPE: RNA SINGLE-STRANDED NEGATIVE-STRAND GENOME-SIZE: 14 kB ENVELOPE: PRESENT CAPSID-SYMMETRY: HELICAL

References

  1. Centers for Disease Control and Prevention (CDC) Antibodies Cross-Reactive to Influenza A (H3N2) Variant Virus and Impact of 2010-11 Seasonal Influenza Vaccine on Cross- Reactive Antibodies - United States MMWR April 13, 2012 / 61(14);237-241 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6114a1.htm
  2. Centers for Disease Control and Prevention (CDC) Update: Influenza A (H3N2)v Transmission and Guidelines - Five States, 2011 MMWR January 6, 2012 / 60(51);1741-1744 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6051a4.htm
  3. Centers for Disease Control and Prevention (CDC) Press Briefing Transcript CDC Telebriefing: Influenza A (H3N2) Variant Virus Friday, August 3, 2012 http://www.cdc.gov/media/releases/2012/t0803_h3n2_variant_virus.html
  4. Associated Press, Aug 9, 2012 CDC: 158 cases of new swine flu strain from pigs http://news.yahoo.com/cdc-158-cases-swine-flu-strain-pigs-174243040.html
  5. Young K, Sofair A, Chavey WE 2014-15 Flu Vaccine Not a Perfect Match to Circulating Viruses Physician's First Watch, Dec 5, 2014 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org
  6. Shenoy ES, Lai PS, Shepard JA, Kradin RL Case 39-2015 - A 22-Year-Old Man with Hypoxemia and Shock. N Engl J Med 2015; 373:2456-2466. December 17, 2015 PMID: 26672848 http://www.nejm.org/doi/full/10.1056/NEJMcpc1507212
  7. Centers for Disease Control and Prevention (CDC) Seasonal Influenza (Flu): FluView http://www.cdc.gov/flu/weekly/