Contents

Search

influenza A H1N1 virus (swine flu virus, Spanish flu virus)

Epidemiology: - first surfaced in 2009 - predominant ciculating virus in 2013-2014 flu season [3] - etiologic agent of 1918 Spanish flu [4] - started in Spring of 2018, dissipated over Summer, returned with a vengeance in the fall Pathology: - etiologic agent of swine flu/ avian flu Laboratory: - influenza virus A serology - influenza virus A H1 Ab in serum - influenza virus A N1 Ab in serum - influenza virus A H1 antigen - influenza virus A H1 RNA - influenza virus A neuraminidase RNA - influenza virus identified by culture Complications: - pregnant women are at increased risk for influenza- associated complications [5] Management: - neuraminidase inhibitor use among patients hospitalized with 2009 pandemic H1N1 associated with 19% lower mortality [5]

Related

rRT-PCR Swine Flu Panel; influenza A H1N1 rRT-PCR swine flu

General

influenza A virus

Properties

KINGDOM: virus GENOME-TYPE: RNA SINGLE-STRANDED NEGATIVE-STRAND GENOME-SIZE: 14 kB ENVELOPE: PRESENT CAPSID-SYMMETRY: HELICAL

References

  1. Centers for Disease Control and Prevention (CDC). Update: Infections with a swine-origin influenza A (H1N1) virus - United States and other countries, April 28, 2009. MMWR Morb Mortal Wkly Rep 2009 Apr 28; 58d:1. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0428a2.htm
  2. Centers for Disease Control and Prevention (CDC). Update: Drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009. MMWR Morb Mortal Wkly Rep 2009 Apr 28; 58d:1. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm58d0428a1.htm
  3. CDC Health Advisory. December 24, 2013, Notice to Clinicians: Early Reports of pH1N1-Associated Illnesses for the 2013-14 Influenza Season. http://emergency.cdc.gov/HAN/han00359.asp
  4. Taubenberger J and Morens D Centers for Disease Control and Prevention (CDC). Emerging Infectious Diseases. 12(1) Jan 2006 1918 Influenza: the Mother of All Pandemics http://wwwnc.cdc.gov/eid/article/12/1/05-0979_article.htm
  5. Muthuri SG et al Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1 virus infection: a meta-analysis of individual participant data Lancet Respir Med article. March 19, 2014 PMID: 24815805 http://download.thelancet.com/flatcontentassets/pdfs/S2213260014700414.pdf
  6. Rasmussen SA, Jamieson DJ 2009 H1N1 Influenza and Pregnancy - 5 Years Later. N Engl J Med 2014; 371:1373-1375. October 9, 2014 PMID: 25295498 http://www.nejm.org/doi/full/10.1056/NEJMp1403496