Search
infantile spasm; West syndrome; Blitz-Nick-salaam attacks; hypsarrhythmia; lightning spasms
Management:
- ACTH
- low-dose is probably as effective as high-dose
- may result in better long-term cognitive outcomes than vigabatrin
- vigabatrin not available in US
- insufficient evidence to support treatment with ketogenic diet or other antiepileptic drugs
Prognosis
- shorter time between spasm onset & treatment is associated with better developmental outcome
General
spasm
References
- Go CY et al
Evidence-based guideline update: Medical treatment of infantile
spasms: Report of the Guideline Development Subcommittee of the
American Academy of Neurology and the Practice Committee of the
Child Neurology Society.
Neurology 2012 Jun 12; 78:1974
PMID: 22689735