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infantile neuronal ceroid lipofuscinosis 1 (Hagberg-Santavuori type, CLN1)

Genetics: -> mutation in gene for palmitoyl protein thioesterase-1 Clinical manifestations: 1) mental retardation 2) speech loss 3) minor motor seizures 4) hypotonia 5) ataxia 6) myoclonic jerks 7) microcephaly 8) optic atrophy 9) blindness 10) premature death (8-11 years of age)

Related

chromosomal aberration lipofuscin palmitoyl protein thioesterase 1; palmitoyl-protein hydrolase 1 (PPT1, PPT)

General

infantile neuronal ceroid lipofuscinosis (INCL)

Properties

ACCUMULATION: lipofuscin ceroid

Database Correlations

OMIM correlations