inclusion body

Structures formed in the nucleus or cytoplasm (or both) of cells infected with virus* or other infectious agent. Etiology: Nuclear inclusion bodies: 1) granular, hyaline or amorphous (Cowdry type A) a) Herpes simplex b) yellow fever 2) Cowdry type B a) Rift Valley fever b) poliomyelitis Cytoplasmic inclusion bodies: 1) acidophilic a) variola b) vaccinia c) rabies d) molluscum contagiosum 2) basophilic a) trachoma b) psittacosis c) lymphogranuloma venereum Erythrocyte inclusion bodies: - Plasmodium (malaria) - Babesia Laboratory: - mannose eosin methylene blue & Giemsa stain render inclusion bodies visible by light microscopy. - viral inclusion bodies in specimen * Inclusion bodies may contain infectious viral particles. Non-viral forms of inclusion bodies may occur (i.e. inclusion body myositis)

References

Stedman's Medical Dictionary 27th ed, Williams & Wilkins, Baltimore, 1999