inner centromere protein (INCENP)

Function: - component of the chromosomal passenger complex - probably acts through association with AURKB or AURKC - seems to bind directly to microtubules - controls the kinetochore localization of BUB1 - phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP - interacts with H2AFZ - interacts with CBX3 - interacts with tubulin beta chain - interacts with AURKB & AURKC - interacts with EVI5. interacts with CDCA8 & BIRC5 - interacts with CBX5 - POGZ & INCENP compete for interaction with CBX5 - interacts with POGZ - interacts with JTB Structure: - homodimer or heterodimer - belongs to the INCENP family Compartment: - chromosome, centromere - cytoplasm, cytoskeleton, spindle - nucleus. chromosome, centromere, kinetochore - ocalizes to inner kinetochore - localizes on chromosome arms & inner centromeres from prophase through metaphase & then transferring to the spindle midzone & midbody from anaphase through cytokinesis - colocalizes with AURKB at mitotic chromosomes Alternative splicing: named isoforms=2

General

centromere protein phosphoprotein

Properties

SIZE: entity length = 918 aa MW = 105 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: Ser phosphorylation site {S50} Ser phosphorylation site {S72} Tyr phosphorylation site {Y73} Ser phosphorylation site {S91} Ser phosphorylation site {S93} Ser phosphorylation site {S94} Ser phosphorylation site {S103} Ser phosphorylation site {S106} Ser phosphorylation site {S119} Ser phosphorylation site {S142} Ser phosphorylation site {S143} Thr phosphorylation site {T145} Ser phosphorylation site {S148} Thr phosphorylation site {T150} Thr phosphorylation site {T195} Ser phosphorylation site {S197} Thr phosphorylation site {T199} Thr phosphorylation site {T213} Ser phosphorylation site {S214} Ser phosphorylation site {S218} Thr phosphorylation site {T219} Ser phosphorylation site {S230} Ser phosphorylation site {S235} Thr phosphorylation site {T239} Ser phosphorylation site {S263} Ser phosphorylation site {S269} Ser phosphorylation site {S275} Ser phosphorylation site {S291} Thr phosphorylation site {T292} Thr phosphorylation site {T294} Ser phosphorylation site {S296} Thr phosphorylation site {T298} Ser phosphorylation site {S306} Ser phosphorylation site {S311} Ser phosphorylation site {S312} Ser phosphorylation site {S314} Ser phosphorylation site {S350} Ser phosphorylation site {S373} Ser phosphorylation site {S400} Thr phosphorylation site {T406} Ser phosphorylation site {S411} Thr phosphorylation site {T412} Ser phosphorylation site {S420} Ser phosphorylation site {S421} Thr phosphorylation site {T424} Ser phosphorylation site {S446} Ser phosphorylation site {S458} Ser phosphorylation site {S476} Thr phosphorylation site {T478} Ser phosphorylation site {S480} Ser phosphorylation site {S481} Thr phosphorylation site {T507} Thr phosphorylation site {T509} Ser phosphorylation site {S510} Ser phosphorylation site {S514} coiled coil {528-791} Thr phosphorylation site {T793} Ser phosphorylation site {S798} Tyr phosphorylation site {Y822} Ser phosphorylation site {S828} Ser phosphorylation site {S831} Thr phosphorylation site {T832} Thr phosphorylation site {T892} Ser phosphorylation site {S893} Ser phosphorylation site {S894} Ser phosphorylation site {S899} Ser phosphorylation site {S914}

Database Correlations

OMIM 604411 UniProt Q9NQS7 PFAM correlations Entrez Gene 3619 Kegg hsa:3619

References

UniProt :accession Q9NQS7