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polio virus vaccine, inactivated (IPOL, IPV, Poliovax, Salk vaccine)

Indications: active immunization against poliovirus Contraindications: 1) acute febrile illness 2) may administer during common cold 3) hypersensitivity to streptomycin or neomycin pregnancy-category C safety in lactation ? Dosage: (4 doses) Primary immunization: (begin at 6 months of age) 1) three 0.5 mL injections SC 2) the 1st 2 doses at intervals of 8 weeks 3) the 3rd dose 6-12 months after the 2nd dose Booster: - all children who have received 3-dose primary immunization before their 4th birthday should receive a booster of 0.5 mL SC before entering school (4-6 years of age) [3] - shortest interval after the 3rd dose is 6 months [3] Injection: 1) suspension of 3 types of poliovirus (1,2 & 3) grown in human diploid cell cultures (0.5 mL) 2) the vaccine should be perfectly clear & pink or red in color Pharmacokinetics: elimination: liver Adverse effects: 1) most common (1-10%) - skin rash, fever > 101.3, inflammation at injection site 2) uncommon (< 1%) - dyspnea, erythema, tiredness, weakness, Guillain Barre syndrome, fussiness, sleepiness, crying, decreased appetite Drug interactions: 1) may temporarily suppress tuberculin skin reactivity (4-6 weeks) 2) immunosuppressive agents 3) immune globulin

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polio virus

General

poliovirus vaccine

References

  1. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  2. Department of Veterans Affairs, VA National Formulary
  3. Centers for Disease Control (CDC) Updated Recommendations of the Advisory Committee on Immunization Practices (ACIP) Regarding Routine Poliovirus Vaccination MMWR August 7, 2009 / 58(30);829-830 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5830a3.htm

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acellular pertussis vaccine/diphtheria toxoid/haemophilus B vaccine/hepatitis B vaccine/poliovirus inactivated vaccine/tetanus toxoid (DtaP-HepB-IPV) acellular pertussis vaccine/diphtheria toxoid/hepatitis B vaccine/poliovirus inactivated vaccine/tetanus toxoid (DtaP-HepB-IPV) acellular pertussis vaccine/diphtheria toxoid/poliovirus vaccine inactivated/tetanus toxoid (Quadracel, DTaP-IPV, Kinrix) acellular pertussis vaccine/hepatitis b surface antigen/hepatitis b vaccine/poliovirus vaccine inactivated/tetanus toxoid acellular pertussis vaccine/poliovirus vaccine inactivated/tetanus toxoid diphtheria toxoid/poliovirus vaccine inactivated/tetanus toxoid