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importin alpha subunit

Recognizes nuclear localization signal NLS.

Specific

importin alpha-2 subunit (karyopherin alpha-2 subunit, KPNA2, SRP1-alpha, recombination-activating gene (RAG) cohort protein 1, RCH1) importin alpha-3 subunit (karyopherin alpha-3 subunit, KPNA3) importin alpha-4 subunit (karyopherin alpha-4 subunit, KPNA4, Qip1 protein) importin alpha-6 subunit (karyopherin alpha-5 subunit, KPNA5) importin alpha-7 subunit (karyopherin alpha-6 subunit, KPNA6, IPOA7) importin alpha-8 subunit (karyopherin subunit alpha-7, KPNA7)

General

protein subunit

Properties

SIZE: MW = 55-60 kD MOTIF: binding site FOR-BINDING-OF: nuclear protein FOR-BINDING-VIA: nuclear translocation signal

References

  1. Nigg EA, Baeuerle PA, Luhrmann R. Nuclear import-export: in search of signals and mechanisms. Cell. 1991 Jul 12;66(1):15-22. Review. No abstract available. PMID: 1712670
  2. Vandromme M et al Regulation of transcription factor localization: fine-tuning of gene expression. Trends Biochem Sci. 1996 Feb;21(2):59-64. Review. PMID: 8851662

Component-of

importin complex (NLS-binding protein)