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importin 11 (Ran-binding protein 11, RanBP11, IPO11)
Function:
- nuclear protein import as nuclear transport receptor
- receptor for nuclear localization signals (NLS) in cargo substrates
- thought to mediate docking of importin/substrate complex to the nuclear pore complex through binding to nucleoporin
- the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism
- at the nucleoplasmic side of the nuclear pore complex, Ran binds to the importin, the importin/substrate complex dissociates & importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran
- directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- & GDP-bound forms of Ran between the cytoplasm & nucleus
- mediates the nuclear import of UBE2E3, & of RPL12 (putative)
- interacts with UBE2E3 & RPL12
Structure:
- belongs to the importin beta family
- contains 15 HEAT repeats
- contains 1 importin N-terminal domain
Compartment: cytoplasm, nucleus
Related
importin complex (NLS-binding protein)
Ran-binding protein M; Ran-binding protein 9; RanBP9; BPM-L; BPM90; RanBPM; RanBP7 (RANBP9, RANBPM)
General
importin beta subunit
Properties
SIZE: entity length = 975 aa
MW = 113 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Importin N-terminal {28-100}
HEAT repeat {123-160}
HEAT repeat {209-248}
HEAT repeat {318-356}
HEAT repeat {422-459}
HEAT repeat {473-509}
HEAT repeat {511-548}
HEAT repeat {555-593}
HEAT repeat {600-636}
HEAT repeat {640-677}
HEAT repeat {683-720}
HEAT repeat {743-764}
HEAT repeat {765-804}
HEAT repeat {819-849}
HEAT repeat {850-887}
HEAT repeat {957-974}
Database Correlations
UniProt Q9UI26
Pfam PF03810
Kegg hsa:5119
References
UniProt :accession Q9UI26