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importin complex (NLS-binding protein)
Function:
- essential for step 1 of nuclear protein transport into the nucleus: binding to the nuclear envelope.
Related
exportin
General
adenosine triphosphatase (ATPase)
carrier protein (transporter)
multisubunit protein
Properties
MOTIF: active site
MOTIF: adenine nucleotide-binding site
SUBUNITS: importin alpha subunit
MOTIF: binding site
FOR-BINDING-OF: nuclear protein
FOR-BINDING-VIA: nuclear translocation signal
importin beta subunit
MOTIF: binding site
FOR-BINDING-OF: nuclear membrane
References
- Vandromme M et al
Regulation of transcription factor localization: fine-tuning
of gene expression.
Trends Biochem Sci. 1996 Feb;21(2):59-64. Review.
PMID: 8851662
Components
importin alpha subunit
importin beta subunit