immune dysfunction in diabetes mellitus

Pathology: immunological distubances induced by hyperglycemia: 1) abnormalities in granulocyte adherence, chemotaxis, phagocytosis & microbicidal function 2) inhibition of attachment of complement C3 to microbial surfaces predisposition to infection: 1) repetitive skin break a) insulin injections b) trauma related to neuropathy & vascular disease, especially diabetic foot ulcer 2) diabetic women have higher rates of bacteriuria - more likely to develop upper urinary tract infection 3) glycosuria may promote bladder colonization with Candida or Torulopsis glabrata 4) rhinocerebral mucormycosis 5) malignant otitis externa caused by Pseudomonas aeruginosa

General

mixed cellular & humoral immune dysfunction diabetes mellitus complication

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998