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imipenem cilastatin/relebactam (Recarbrio)
Indications:
- complicated urinary tract infection
- complicated intra-abdominal infection
- bacterial pneumonia: hospital-acquired pneumonia & ventilator-associated pneumonia [2,3]
* gram negative infections
Adverse effects:
- diarrhea, nausea, headache, fever, elevated serum transaminases Antibiotic susceptibility:
- Enterobacter cloacae
- Escherichia coli
- Klebsiella aerogenes
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Bacteroides caccae
- Bacteroides fragilis
- Bacteroides ovatus,
- Bacteroides stercoris
- Bacteroides thetaiotaomicron
- Bacteroides uniformis
- Bacteroides vulgatus
- Citrobacter freundii
- Enterobacter cloacae
- Escherichia coli
- Fusobacterium nucleatum
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae,
- Parabacteroides distasonis
- Pseudomonas aeruginosa
Drug interactions:
- ganciclovir in combination may increase risk of generalized seizures
- Recarbrio may reduce serum level of valproic acid or divalproex
General
antibiotic combination
References
- Brown T
FDA Approves Drug Trio for UTI, Intra-abdominal Infection.
Medscape - Jul 17, 2019.
https://www.medscape.com/viewarticle/915723
- FDA News Release. July 17, 2019
FDA approves new treatment for complicated urinary tract and
complicated intra-abdominal infections [press release]. Rockville, MD.
https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-complicated-urinary-tract-and-complicated-intra-abdominal-infections
- FDA News Release. June 4, 2020
FDA Approves Antibiotic to Treat Hospital-Acquired Bacterial
Pneumonia and Ventilator-Associated Bacterial Pneumonia.
https://www.fda.gov/news-events/press-announcements/fda-approves-antibiotic-treat-hospital-acquired-bacterial-pneumonia-and-ventilator-associated
- Rapid Review Quiz: Hospital-Acquired Pneumonia
Medscape. Sept 15, 2022
https://reference.medscape.com/viewarticle/980567
- HIGHLIGHTS OF PRESCRIBING INFORMATION
imipenem, cilastatin & relebactam (Recarbrio) for injection,
intravenous use
https://www.merck.com/product/usa/pi_circulars/r/recarbrio/recarbrio_pi.pdf
Components
cilastatin
imipenem cilastatin (Primaxin)
relebactam