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interleukin-9; IL-9; cytokine P40; T-cell growth factor P40 (IL9)

Function: - promotes growth of helper CD4+ but not cytotoxic CD8+ T cells (IL-2 & IL-4 independent) - BFU-E stimulation Structure: belongs to the IL-7/IL-9 family Compartment: secreted

Related

interleukin-9 receptor (IL9 receptor, CD129)

General

interleukin

Properties

SIZE: entity length = 144 aa MW = 16 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} N-glycosylation site {N50} N-glycosylation site {N63} N-glycosylation site {N78} N-glycosylation site {N114} SECRETED-BY: T-cell

Database Correlations

OMIM 146931 UniProt P15248 Pfam PF01415 Entrez Gene 3578 Kegg hsa:3578

References

  1. UniProt :accession P15248
  2. Wikipedia; Note: interleukin-9 entry http://en.wikipedia.org/wiki/interleukin_9
  3. SeattleSNPs http://pga.gs.washington.edu/data/il9/1) Yang YC, Ricciardi S, Ciarletta A, Calvetti J,
  4. Kelleher K, Clark SC. Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40. Blood. 1989 Nov 1;74(6):1880-4. PMID: 2508790
  5. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908