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interleukin-36 beta; FIL1 eta; interleukin-1 eta; IL-1 eta; interleukin-1 family member 8; IL-1F8; interleukin-1 homolog 2; IL-1H2 (IL36B, IL1F8, IL1H2)

Function: - stimulates production of interleukin-6 & interleukin-8 in synovial fibrobasts, articular chondrocytes & mature adipocytes - induces expression of some of antimicrobial peptides including beta-defensin 4 & beta-defensin 103 - induces some matrix metalloproteases Structure: belongs to the IL-1 family Compartment: secreted (putative) Alternative splicing: named isoforms=2 Expression: - expressed at low levels in tonsil, bone marrow, heart, placenta, lung, testis & colon - not expressed in any hematopoietic cell lines - not detected in adipose tissue - expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin - increased levels are not detected in inflamed joint tissue - induced by proinflammatory cytokines IL1A, IL1B & TNF in synovial fibroblasts - induced by IL1A & TNF in keratinocytes - constitutive expression in articular chondrocytes Pharmacology: - IL-36 inhibitor spesolimab is a investigational agent to treat pustular psoriasis

General

interleukin

Properties

SIZE: entity length = 164 aa MW = 19 kD COMPARTMENT: extracellular compartment

Database Correlations

OMIM 605508 UniProt Q9NZH7 Entrez Gene 27177 Kegg hsa:27177

References

  1. UniProt :accession Q9NZH7
  2. Wikipedia; Note: interleukin-1 entry http://en.wikipedia.org/wiki/interleukin_1
  3. SeattleSNPs http://pga.gs.washington.edu/data/il1f8/