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interleukin-31 receptor (IL13 receptor)
Function:
- activates STAT3 & to a lower extent STAT1 & STAT5
- may function in skin immunity
Structure:
- heterodimer of IL31RA & OSMR IL-12 receptor
Related
interleukin-31 (IL-31) (IL31)
General
interleukin receptor
multisubunit protein
Properties
COMPARTMENT: plasma membrane
SUBUNITS: Interleukin-31 receptor A
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
fibronectin type III domain or F3 module {22-116}
MOTIF: N-glycosylation site {N37}
N-glycosylation site {N67}
N-glycosylation site {N93}
fibronectin type III domain or F3 module {121-222}
MOTIF: N-glycosylation site {N166}
N-glycosylation site {N187}
fibronectin type III domain or F3 module {223-315}
MOTIF: N-glycosylation site {N277}
N-glycosylation site {N283}
fibronectin type III domain or F3 module {319-416}
MOTIF: N-glycosylation site {N395}
fibronectin type III domain or F3 module {421-512}
MOTIF: N-glycosylation site {N455}
N-glycosylation site {N504}
transmembrane domain {520-540}
oncostatin-M specific receptor subunit beta
MOTIF: signal sequence {1-27}
N-glycosylation site {N163}
cysteine residue {C245}
MODIFICATION: cysteine residue {C255}
cysteine residue {C255}
MODIFICATION: cysteine residue {C245}
N-glycosylation site {N326}
fibronectin type III domain or F3 module {332-424}
MOTIF: N-glycosylation site {N380}
WSXWS motif {415-419}
fibronectin type III domain or F3 module {430-524}
MOTIF: N-glycosylation site {N446}
fibronectin type III domain or F3 module {526-619}
MOTIF: N-glycosylation site {N580}
fibronectin type III domain or F3 module {625-732}
transmembrane domain {741-761}
box1 motif
SITE: 770-778
FOR-BINDING-OF: Janus kinase (JAK)
References
UniProt :accession Q8NI17
Components
Interleukin-31 receptor A (IL-31RA, cytokine receptor-like 3, Gp130-like monocyte receptor, GLM-R, HGLM-R, Gp130-like receptor, IL31RA, CRL3, GPL, UNQ6368/PRO21073/PRO21384)
oncostatin-M specific receptor subunit beta (OSMR, OSMRB)