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CD122; interleukin-2 receptor subunit beta; IL-2 receptor beta; P70-75; p75 (IL2RB)

Function: - receptor for interleukin-2 - beta subunit is involved in receptor mediated endocytosis & transduces the mitogenic signals of IL2 - beta subunit is an intermediate affinity IL2 receptor - associates with cytokine receptor gamma - interacts with SHB upon interleukin stimulation - interacts with HTLV-1 accessory protein p12I - associates with/activates lck, fyn, & lyn [5]; may do so through association with JAK3 Structure: - the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding - the box 1 motif is required for JAK interaction &/or activation - belongs to the type I cytokine receptor family, type 4 subfamily - contains 1 fibronectin F3 module Compartment: membrane

Interactions

molecular events

Related

CD122 (c-kit protein) cells in blood CD122 Ag in tissue IL2 receptor-beta gene interleukin-2; IL-2; T-cell growth factor; TCGF (IL2)

General

cluster-of-differentiation antigen; cluster designation antigen; CD antigen glycoprotein hematopoietin receptor superfamily protein subunit

Properties

SIZE: entity length = 551 aa MW = 61 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-26} N-glycosylation site {N29} cysteine residue {C36} MODIFICATION: cysteine residue {C46} N-glycosylation site {N43} cysteine residue {C46} MODIFICATION: cysteine residue {C36} cysteine residue {C59} MODIFICATION: cysteine residue {C110} N-glycosylation site {N71} cysteine residue {C74} MODIFICATION: cysteine residue {C86} cysteine residue {C86} MODIFICATION: cysteine residue {C74} cysteine residue {C110} MODIFICATION: cysteine residue {C59} fibronectin type III domain or F3 module {131-229} MOTIF: N-glycosylation site {N149} WSXWS motif {220-224} transmembrane domain {241-265} box1 motif SITE: 278-286 FOR-BINDING-OF: Janus kinase (JAK) MISC-INFO: LIGAND = INTERLEUKIN_2

Database Correlations

OMIM 146710 UniProt P14784 Entrez Gene 3560 Kegg hsa:3560

References

  1. UniProt :accession P14784
  2. SeattleSNPs http://pga.gs.washington.edu/data/il2rb/
  3. Saltzman EM, Luhowskyj SM, Casnellie JE. The 75,000-dalton interleukin-2 receptor transmits a signal for the activation of a tyrosine protein kinase. J Biol Chem. 1989 Nov 25;264(33):19979-83. PMID: 2511197
  4. Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: 1334470
  5. Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: 8048164

Component-of

interleukin-2 receptor (IL2 receptor)