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CD25; interleukin-2 receptor alpha chain; IL-2 receptor alpha subunit; IL-2-RA; IL2-RA; p55; TAC antigen (IL2RA)
Function:
- low-affinity receptor for interleukin-2
- insufficient alone for transducing signal of IL-2
Structure: contains 2 Sushi (CCP/SCR) domains
Compartment: membrane
Pathology:
- genetic variations in IL2RA are associated with susceptibility to insulin-dependent diabetes mellitus type 10 (IDDM10)
Interactions
molecular events
Related
basiliximab (Simulect)
CD25 Ag in tissue
CD25 cells in specimen
IL2 receptor-alpha gene
interleukin-2 receptor alpha in serum
interleukin-2; IL-2; T-cell growth factor; TCGF (IL2)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
protein subunit
Properties
SIZE: entity length = 272 aa
MW = 31 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
Sushi domain {22-84}
MOTIF: cysteine residue {C24}
MODIFICATION: cysteine residue {C168}
cysteine residue {C49}
MODIFICATION: cysteine residue {C80}
cysteine residue {C51}
MODIFICATION: cysteine residue {C82}
cysteine residue {C67}
MODIFICATION: cysteine residue {C125}
N-glycosylation site {N70}
cysteine residue {C80}
MODIFICATION: cysteine residue {C49}
cysteine residue {C82}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N89}
Sushi domain {123-186}
MOTIF: cysteine residue {C125}
MODIFICATION: cysteine residue {C67}
cysteine residue {C152}
MODIFICATION: cysteine residue {C184}
cysteine residue {C168}
MODIFICATION: cysteine residue {C24}
cysteine residue {C184}
MODIFICATION: cysteine residue {C152}
Thr glycosylation site {T218}
Thr glycosylation site {T224}
Thr glycosylation site {T229}
Thr glycosylation site {T237}
transmembrane domain {241-259}
Database Correlations
OMIM correlations
MORBIDMAP 147730
UniProt P01589
Pfam PF00084
Entrez Gene 3559
Kegg hsa:3559
References
- UniProt :accession P01589
- IL2RAbase; Note: IL2RA mutation db
http://bioinf.uta.fi/IL2RAbase/
- SeattleSNPs
http://pga.gs.washington.edu/data/il2ra/
- Saltzman EM, Luhowskyj SM, Casnellie JE.
The 75,000-dalton interleukin-2 receptor transmits a
signal for the activation of a tyrosine protein kinase.
J Biol Chem. 1989 Nov 25;264(33):19979-83.
PMID: 2511197
- Takeshita T et al
Cloning of the gamma chain of the human IL-2 receptor.
Science. 1992 Jul 17;257(5068):379-82.
PMID: 1631559
Component-of
interleukin-2 receptor (IL2 receptor)