Search
interleukin-2 receptor (IL2 receptor)
IL-2 alpha (low affinity) & IL-2 beta (intermediate affinity) IL-2 receptor subunits bind to form high affinity receptor. Cytokine receptor gamma may be 3rd subunit.
Interactions
molecular events
Related
interleukin 2 (IL2) receptor in specimen
interleukin 2 (IL2) receptor soluble in serum/plasma
interleukin-2; IL-2; T-cell growth factor; TCGF (IL2)
General
interleukin receptor
multisubunit protein
Properties
COMPARTMENT:
plasma membrane
CELL: T-cell
B lymphocyte
monocyte
MOTIF:
ligand-binding site
transmembrane domain
cysteine residue
box1 motif
FOR-BINDING-OF: Janus kinase (JAK)
box2 motif
FOR-BINDING-OF: Janus kinase (JAK)
Tyr phosphorylation site
SUBUNITS:
IL-2 receptor alpha
MOTIF: signal sequence {1-21}
Sushi domain {22-84}
MOTIF: cysteine residue {C24}
MODIFICATION: cysteine residue {C168}
cysteine residue {C49}
MODIFICATION: cysteine residue {C80}
cysteine residue {C51}
MODIFICATION: cysteine residue {C82}
cysteine residue {C67}
MODIFICATION: cysteine residue {C125}
N-glycosylation site {N70}
cysteine residue {C80}
MODIFICATION: cysteine residue {C49}
cysteine residue {C82}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N89}
Sushi domain {123-186}
MOTIF: cysteine residue {C125}
MODIFICATION: cysteine residue {C67}
cysteine residue {C152}
MODIFICATION: cysteine residue {C184}
cysteine residue {C168}
MODIFICATION: cysteine residue {C24}
cysteine residue {C184}
MODIFICATION: cysteine residue {C152}
Thr glycosylation site {T218}
Thr glycosylation site {T224}
Thr glycosylation site {T229}
Thr glycosylation site {T237}
transmembrane domain {241-259}
IL-2 receptor beta
MOTIF: signal sequence {1-26}
N-glycosylation site {N29}
cysteine residue {C36}
MODIFICATION: cysteine residue {C46}
N-glycosylation site {N43}
cysteine residue {C46}
MODIFICATION: cysteine residue {C36}
cysteine residue {C59}
MODIFICATION: cysteine residue {C110}
N-glycosylation site {N71}
cysteine residue {C74}
MODIFICATION: cysteine residue {C86}
cysteine residue {C86}
MODIFICATION: cysteine residue {C74}
cysteine residue {C110}
MODIFICATION: cysteine residue {C59}
fibronectin type III domain or F3 module {131-229}
MOTIF: N-glycosylation site {N149}
WSXWS motif {220-224}
transmembrane domain {241-265}
box1 motif
SITE: 278-286
FOR-BINDING-OF: Janus kinase (JAK)
Database Correlations
OMIM 147730
MORBIDMAP 147730
References
Saltzman et al J Biol Chem 264(33):19979 1989
Components
CD122; interleukin-2 receptor subunit beta; IL-2 receptor beta; P70-75; p75 (IL2RB)
CD25; interleukin-2 receptor alpha chain; IL-2 receptor alpha subunit; IL-2-RA; IL2-RA; p55; TAC antigen (IL2RA)