interleukin-23 (IL23)

Function: - heterodimeric cytokine - functions in innate & adaptive immunity - IL-23 induces autoimmune inflammation & thus may be responsible for autoimmune inflammatory diseases & may be important for tumorigenesis - IL-23 may constitute with IL-17 an acute response to infection in peripheral tissue - IL-23 binds to heterodimeric receptor complex composed of IL12RB1 & IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells & promotes production of proinflammatory cytokines Pathology: - IL-23 induces autoimmune inflammation, thus may be responsible for autoimmune inflammatory diseases & may be important for tumorigenesis

General

interleukin molecular complex

Properties

COMPARTMENT: extracellular compartment SUBUNITS: interleukin-23 subunit alpha MOTIF: signal sequence {1-19} interleukin-12 subunit beta MOTIF: signal sequence {1-22} immunoglobulin superfamily domain {23-106} MOTIF: cysteine residue {C50} MODIFICATION: cysteine residue {C90} cysteine residue {C90} MODIFICATION: cysteine residue {C50} cysteine residue {C131} MODIFICATION: cysteine residue {C142} N-glycosylation site {N135} cysteine residue {C142} MODIFICATION: cysteine residue {C131} cysteine residue {C170} MODIFICATION: cysteine residue {C193} cysteine residue {C193} MODIFICATION: cysteine residue {C170} cysteine residue {C199} MODIFICATION: cysteine residue {C96 IN IL12A} N-glycosylation site {N222} fibronectin type III domain or F3 module {235-327} MOTIF: cysteine residue {C300} MODIFICATION: cysteine residue {C327} cysteine residue {C327} MODIFICATION: cysteine residue {C300}

References

UniProt :accession Q9NPF7

Components

interleukin-12 subunit beta; IL-12B; cytotoxic lymphocyte maturation factor 40 kD subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2 (IL12B NKSF2) interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; interleukin-23 subunit p19; IL-23p19 (IL23A, SGRF, UNQ2498/PRO5798)