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interleukin-1 receptor (IL1R)

IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1.

Interactions

molecular events

Related

interleukin-1 receptor accessory protein (Three immunoglobulin domain-containing IL-1 receptor-related) interleukin-1 receptor antagonist protein; IL-1ra; IL-1RN; IRAP; IL1 inhibitor; ICIL-1RA (IL1RN, IL1F3, IL1RA) interleukin-1; lymphocyte-activating factor (IL1) Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; adaptor protein Wyatt; MyD88 adapter-like protein (TIRAP, MAL)

Specific

CDw121A, interleukin-1 receptor type I; IL-1R-1; IL-1RT1; IL-1R-alpha; p80; CD121 antigen-like family member A; CD121a (IL1R1, IL1RA, IL1RT1) CDw121b; interleukin-1 receptor type II; IL-1R-2; IL-1R-beta; CD121 antigen-like family member B; CDw121b; CD121b antigen; CD121 (IL1R2, IL1RB)

General

interleukin receptor

Properties

COMPARTMENT: plasma membrane MOTIF: ligand-binding site FOR-BINDING-OF: interleukin-1 transmembrane domain cysteine residue box1 motif FOR-BINDING-OF: Janus kinase (JAK) box2 motif FOR-BINDING-OF: Janus kinase (JAK) Tyr phosphorylation site

References

  1. O'Neill et al J Biol Chem 265:3146 1990
  2. Colatta et al Science 261:472 1993