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interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; binetrakin; lymphocyte stimulatory factor 1; pitrakinra (IL4)
Function:
- synergy with G-CSF & erythropoietin
- in conjunction with IL-13, stimulates responding B-cells to switch to IgE production
- role in at least several B-cell activation processes as well as of other cell types
- costimulator of DNA-synthesis
- induces expression of class II MHC molecules on resting B-cells
- enhances both secretion & cell surface expression of IgE & IgG1
- regulates expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes & monocytes
Structure: belongs to the IL-4/IL-13 family
Compartment: secreted
Alternative splicing: named isoforms=2
Pathology:
- polymorphisms in IL4 may be a cause of susceptibility to ischemic stroke
Related
interleukin 4 (IL4) in serum/plasma
interleukin-4 receptor (IL4 receptor)
General
interleukin
Properties
SIZE: entity length = 153 aa
MW = 17 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
cysteine residue {C27}
MODIFICATION: cysteine residue {C151}
cysteine residue {C48}
MODIFICATION: cysteine residue {C89}
N-glycosylation site {N62}
cysteine residue {C70}
MODIFICATION: cysteine residue {C123}
cysteine residue {C89}
MODIFICATION: cysteine residue {C48}
cysteine residue {C123}
MODIFICATION: cysteine residue {C70}
cysteine residue {C151}
MODIFICATION: cysteine residue {C27}
SECRETED-BY: T helper 2 cell
mast cell
Database Correlations
OMIM correlations
UniProt P05112
Pfam PF00727
Entrez Gene 3565
Kegg hsa:3565
References
- UniProt :accession P05112
- SeattleSNPs
http://pga.gs.washington.edu/data/il4/
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908
- Scott P
IL-12: initiation cytokine for cell-mediated immunity
Science 260:496 1993
PMID: 8097337 (secretion)
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Entrez Gene :accession 3565