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interleukin-1-like protein 1; interleukin-36 receptor antagonist protein; FIL1 delta; IL-1-related protein 3; IL-1RP3; interleukin-1 HY1; IL-1HY1; interleukin-1 delta; IL-1 delta; interleukin-1 family member 5; IL-1F5; interleukin-1 receptor antagonist homolog 1; IL-1ra homolog 1; IL-1L1 (IL36RN, FIL1D, IL1F5, IL1HY1, IL1L1, IL1RP3, UNQ1896/PRO4342)
Function:
- specific antagonist of the IL-1 receptor-related protein 2- mediated response to interleukin 1 family member 9 (IL1F9)
- could constitute part of an independent signaling system analogous to IL-1 alpha (IL-1A), IL-1 beta (IL-1B) receptor agonist & interleukin-1 receptor type 1 (IL1R1), that is present in epithelial barriers & takes part in local inflammatory responses
Structure: belongs to the IL-1 family
Compartment: secreted
Expression:
- predominantly expressed in keratinocytes
- not expessed in fibroblasts, endothelial cells or melanocytes
- detected in spleen, brain leukocyte & macrophage cell types
- increased expression in lesional psoriasis skin
- induced by phorbol ester (PMA) & bacterial lipopolysaccharides (LPS) treatment in macrophage cell line
Pathology:
- defects in IL36RN are the cause of generalized pustular psoriasis
General
interleukin-1; lymphocyte-activating factor (IL1)
Properties
SIZE: entity length = 155 aa
MW = 17 kD
COMPARTMENT: extracellular compartment
MOTIF: cysteine residue {C8}
MODIFICATION: cysteine residue {C154}
cysteine residue {C154}
MODIFICATION: cysteine residue {C8}
Database Correlations
OMIM correlations
UniProt Q9UBH0
Pfam PF00340
Entrez Gene 26525
Kegg hsa:26525
References
- UniProt :accession Q9UBH0
- Wikipedia; Note: interleukin-1 entry
http://en.wikipedia.org/wiki/interleukin_1
- SeattleSNPs
http://pga.gs.washington.edu/data/il1f5/