Interleukin-31 receptor A (IL-31RA, cytokine receptor-like 3, Gp130-like monocyte receptor, GLM-R, HGLM-R, Gp130-like receptor, IL31RA, CRL3, GPL, UNQ6368/PRO21073/PRO21384)

Function: - associates with OSMR to form the interleukin-31 receptor which activates STAT3 & to a lower extent STAT1 & STAT5 - may function in skin immunity - heterodimer with OSMR - interacts with JAK1 & STAT3 Structure: - N-glycosylated - belongs to the type I cytokine receptor family, type 2 subfamily - contains 5 fibronectin F3 modules Compartment: cell membrane Alternative splicing: named isoforms=12 Expression: - expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, bone marrow, trachea & skin - detected in all of the myelomonocytic lineage - expressed in CD14- & CD56-positive blood cells & by macrophages (at protein level) - up-regulated by IFNG & lipopolysaccharides Pathology: - up-regulated in lesional keratinocytes of patients with atopic dermatitis

General

membrane protein protein subunit

Properties

SIZE: MW = 83 kD entity length = 732 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} fibronectin type III domain or F3 module {22-116} MOTIF: N-glycosylation site {N37} N-glycosylation site {N67} N-glycosylation site {N93} fibronectin type III domain or F3 module {121-222} MOTIF: N-glycosylation site {N166} N-glycosylation site {N187} fibronectin type III domain or F3 module {223-315} MOTIF: N-glycosylation site {N277} N-glycosylation site {N283} fibronectin type III domain or F3 module {319-416} MOTIF: N-glycosylation site {N395} fibronectin type III domain or F3 module {421-512} MOTIF: N-glycosylation site {N455} N-glycosylation site {N504} transmembrane domain {520-540}

Database Correlations

OMIM 609510 UniProt Q8NI17 Pfam PF00041 Kegg hsa:1333

References

UniProt :accession Q8NI17