Search
interleukin-31 (IL-31) (IL31)
Function:
- activates STAT3 & possibly STAT1 & STAT5 through the IL31 heterodimeric receptor composed of IL31RA & OSMR
- IL31 mayfunction in skin immunity
Compartment: secreted (probable)
Expression:
- detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine & trachea
Pathology:
- up-regulated in skin homing T-cells of patients with atopic dermatitis & in activated circulating T-cells
- up-regulated in lesional biopsies of patients with allergic contact dermatitis
General
interleukin
Properties
SIZE: MW = 18 kD
entity length = 164 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
N-glycosylation site {N67}
N-glycosylation site {N100}
Database Correlations
UniProt Q6EBC2
References
UniProt :accession Q6EBC2