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interleukin-1 alpha; IL-1 alpha; hematopoietin-1 (IL1A, IL1F1)
Function:
- costimulation of T-cells & B-cells
- synergy with GM-CSF
- stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation & proliferation, & fibroblast growth factor activity
- involved in the inflammatory response
- endogenous pyrogens
- stimulates release of prostaglandin & collagenase from synovial cells
- promotes PGE release, fever induction, acute-phase proteins, & activation of endothelial cells
Structure:
- monomer
- similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function
- belongs to the IL-1 family
Compartment:
- secreted
- lack of a specific hydrophobic segment in the precursor suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins
Expression:
- expressed & secreted by activated macrophages
Related
interleukin 1 (IL1) alpha in body fluid
interleukin 1 (IL1) alpha in CSF
interleukin 1 (IL1) alpha in serum/plasma
General
interleukin-1; lymphocyte-activating factor (IL1)
Properties
SIZE: entity length = 271 aa
MW = 31 kD
COMPARTMENT: extracellular compartment
MOTIF: N-glycosylation site {N102}
N-glycosylation site {N141}
Database Correlations
OMIM 147760
UniProt P01583
PFAM correlations
Entrez Gene 3552
Kegg hsa:3552
References
- UniProt :accession P01583
- Wikipedia; Note: interleukin-1 entry
http://en.wikipedia.org/wiki/interleukin_1
- SeattleSNPs
http://pga.gs.washington.edu/data/il1a/
- SHMPD; Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=IL1A