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interleukin-13 (IL13, IL-13, NC30)
Function:
- inhibits inflammatory cytokine (IL-6, IL-1 beta, TNF-alpha, IL-8, gro-B) secretion induced by LPS in monocytes
- synergizes with IL-2 in regulating IFN-gamma synthesis in NK cells
- also enhances proliferation of B-cells & expression of CD23
- in conjunction with IL-4, stimulates responding B-cells to switch to IgE production
- interacts with IL13RA2
Structure: belongs to the IL-4/IL-13 family
Compartment: secreted
Pathology:
- defects in IL13 may be a cause of susceptibility to allergic rhinitis
Note:
- uncertain whether Met-1 or Met-15 is the initiator
Related
interleukin 13 (IL-13) in serum/plasma
interleukin 13 in body fluid
General
glycoprotein
interleukin
Properties
SIZE: MW = 9-17 kD
entity length = 132 aa
entity length = 110 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
N-glycosylation site {N38}
cysteine residue {C48}
MODIFICATION: cysteine residue {C76}
N-glycosylation site {N49}
N-glycosylation site {N57}
cysteine residue {C64}
MODIFICATION: cysteine residue {C90}
N-glycosylation site {N72}
cysteine residue {C76}
MODIFICATION: cysteine residue {C48}
cysteine residue {C90}
MODIFICATION: cysteine residue {C64}
SECRETED-BY: T-cell
Database Correlations
OMIM correlations
MORBIDMAP 147683
UniProt P35225
Pfam PF03487
Entrez Gene 3596
Kegg hsa:3596
References
- Minty et al Nature 362:248 1993
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Entrez Gene :accession 3596