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interleukin-12 subunit beta; IL-12B; cytotoxic lymphocyte maturation factor 40 kD subunit; CLMF p40; IL-12 subunit p40; NK cell stimulatory factor chain 2; NKSF2 (IL12B NKSF2)
Function:
- cytokine
- can act as a growth factor for activated T-cells & NK cells, enhance lytic activity of NK/lymphokine-activated killer cells, & stimulate the production of IFN-gamma by resting lymphocytes
- associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate immunity & adaptive immunity
- IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues
- IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 & IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T- cells & promotes production of proinflammatory cytokines
- IL-23 induces autoimmune inflammation & thus may be responsible for autoimmune inflammatory diseases & may be important for tumorigenesis
Structure:
- C-mannosylated in the recombinant protein
- not yet known for sure if the wild-type protein is also modified
- heterodimer with IL12A, disulfide-linked as interleukin-12
- heterodimer with IL23A, disulfide-linked as interleukin-23
- also secreted as a monomer
- belongs to the type I cytokine receptor family, type 3 subfamily
- contains 1 fibronectin F3 module
- contains 1 Ig-like C2-type domain
Pathology:
- defects in IL12B are a cause of mendelian susceptibility to mycobacterial disease (MSMD)
- polymorphisms in IL12B are a cause of susceptibility to psoriasis type 11
General
protein subunit
Properties
SIZE: entity length = 328 aa
MW = 37 kD
MOTIF: signal sequence {1-22}
immunoglobulin superfamily domain {23-106}
MOTIF: cysteine residue {C50}
MODIFICATION: cysteine residue {C90}
cysteine residue {C90}
MODIFICATION: cysteine residue {C50}
cysteine residue {C131}
MODIFICATION: cysteine residue {C142}
N-glycosylation site {N135}
cysteine residue {C142}
MODIFICATION: cysteine residue {C131}
cysteine residue {C170}
MODIFICATION: cysteine residue {C193}
cysteine residue {C193}
MODIFICATION: cysteine residue {C170}
cysteine residue {C199}
MODIFICATION: cysteine residue {C96 IN IL12A}
N-glycosylation site {N222}
fibronectin type III domain or F3 module {235-327}
MOTIF: cysteine residue {C300}
MODIFICATION: cysteine residue {C327}
cysteine residue {C327}
MODIFICATION: cysteine residue {C300}
Database Correlations
OMIM correlations
UniProt P29460
Pfam PF10420
Entrez Gene 3593
Kegg hsa:3593
References
- UniProt :accession P29460
- IL12Bbase; Note: IL12B mutation db
http://bioinf.uta.fi/IL12Bbase/
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/IL12B
- SeattleSNPs
http://pga.gs.washington.edu/data/il12b/
Component-of
interleukin-23 (IL23)