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interleukin-10 receptor beta chain; IL-10R-B; IL-10R2; cytokine receptor class-II member 4; cytokine receptor family 2 member 4; CRF2-4; CDw210b (IL10RB, CRFB4, D21S58, D21S66)
Function:
- accessory subunit for receptors for IL10 & IL22
- serves as an accessory chain essential for the active IL10 receptor complex & to initiate IL10-induced signal transduction events
Structure:
- belongs to the type II cytokine receptor family
- contains 2 fibronectin F3 modules
Compartment: membrane
Pathology:
- defects in IL10RB are associated with susceptibility to hepatitis B
- defects in IL10RB found in infantile-onset Crohn's disease
General
glycoprotein
membrane protein
protein subunit
Properties
SIZE: entity length = 325 aa
MW = 37 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
N-glycosylation site {N49}
cysteine residue {C66}
MODIFICATION: cysteine residue {C74}
N-glycosylation site {N68}
cysteine residue {C74}
MODIFICATION: cysteine residue {C66}
N-glycosylation site {N102}
fibronectin type III domain or F3 module {113-205}
MOTIF: N-glycosylation site {N161}
cysteine residue {C188}
MODIFICATION: cysteine residue {C209}
cysteine residue {C209}
MODIFICATION: cysteine residue {C188}
transmembrane domain {221-242}
Database Correlations
OMIM correlations
MORBIDMAP 123889
UniProt Q08334
Pfam PF01108
Entrez Gene 3588
Kegg hsa:3588
References
- UniProt :accession Q08334
- SeattleSNPs
http://pga.gs.washington.edu/data/il10rb
- Glocker E-O et al.
Inflammatory bowel disease and mutations affecting the
interleukin-10 receptor.
N Engl J Med 2009 Nov 19; 361:2033
PMID: 19890111
- Kelsall B.
Interleukin-10 in inflammatory bowel disease.
N Engl J Med 2009 Nov 19; 361:2091.
PMID: 19890110
Component-of
interleukin-28 receptor (IL28 receptor)