zinc finger protein Pegasus; Ikaros family zinc finger protein 5 (IKZF5, ZNFN1A5)

Function: - DNA-binding protein - binds to the 5'GNNTGTNG-3' core sequence - transcriptional repressor - self-associates & interacts with other family members IKZF1, IKZF2, IKZF3 AND IKZF4 Structure: - N-terminal zinc fingers are involved in sequence-specific DNA binding & heterotypic associations with other family members - C-terminal zinc fingers mediate homodimerization - belongs to the Ikaros C2H2-type zinc-finger protein family - contains 5 C2H2-type zinc fingers Expression: - expressed in brain, heart, skeletal muscle, kidney, & liver - expressed in the hematopoietic cell lines MOLT-4, NALM-6 & K562 - highly expressed in THP-1 & Mo7e-IL3 cell lines, which have characteristics of myeloid & early megakaryocytic cells, respectively Miscellaneous: 'Pegasus' was the winged horse in Greek mythology

Properties

SIZE: entity length = 419 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 82-104 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 110-132 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 138-161 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 364-386 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 392-416 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 606238 UniProt Q9H5V7 Pfam PF00096 Entrez Gene 64376

References

UniProt :accession Q9H5V7