zinc finger protein Eos; Ikaros family Zn+2 finger protein 4 (IKZF4, KIAA1782, ZNFN1A4, zinc finger protein-1A-4 )

Function: - DNA-binding protein - binds to the 5'GGGAATRCC-3' Ikaros-binding sequence - transcriptional repressor - interacts with SPI1 & MITF to repress transcription of the CTSK & ACP5 promoters via recruitment of corepressors SIN3A & CTBP2 - may be involved in the development of central & peripheral nervous systems - self-associates & interacts with other family members IKZF1, IKZF2, IKZF3 & IKZF5 - interacts with CTBP2, SPI1 & MITF Structure: - N-terminal zinc fingers are involved in sequence- specific DNA binding & heterotypic associations with other family members - C-terminal zinc fingers mediate homodimerization - belongs to the Ikaros C2H2-type zinc-finger protein family - contains 6 C2H2-type zinc fingers Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - highly expressed in skeletal muscle - low levels of expression in heart, thymus, kidney, liver, & spleen - expressed in the hematopoietic cell lines MOLT-4, NALM-6 & K562 - highly expressed in THP-1 & Mo7e-IL3 cell lines, which have characteristics of myeloid & early megakaryocytic cells, respectively Miscellaneous: 'Eos' is a Greek word for rising sun

General

ikaros family zinc finger protein transcriptional silencer (transcriptional repressor)

Properties

SIZE: entity length = 585 aa MW = 64 kD COMPARTMENT: cell nucleus MOTIF: Zn finger C2H2-type SITE: 159-181 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 187-209 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 215-237 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 248-271 EFFECTOR-BOUND: Zn+2 CTBP-binding motif PEDLA {425-429} Zn finger C2H2-type SITE: 530-552 EFFECTOR-BOUND: Zn+2 Zn finger C2H2-type SITE: 558-582 EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 606239 UniProt Q9H2S9 Pfam PF00096 Entrez Gene 64375

References

UniProt :accession Q9H2S9