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IKK-epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; I kappa-B kinase epsilon; IkBKE; IKK-E; inducible I kappa-B kinase; IKK-i (IKBKE, IKKE, IKKI, KIAA0151)
Function:
- part of a PMA-inducible IkB kinase complex distinct from the one containing IKK-alpha, IKK-beta & IKK-gamma
- IKKe phosphorylates Ser-36 but not Ser-32 of IkB alpha
- involved in PMA & T cell receptor induction of NF kappa B but not TNF-alpha or interleukin-1
- role in the immune response (putative)
- may interact with MAVS/IPS1
- interacts with AZI2
- interacts with SIKE
- interacts with TICAM1/TRIF, IRF3 & DDX58/RIG-I; interactions are disrupted by the interaction between IKBKE & SIKE
- autophosphorylated
Structure:
- belongs to the protein kinase superfamily, Ser/Thr protein kinase family, I-kappa-B kinase subfamily
- contains 1 protein kinase domain
Compartment: cytoplasm (probable)
Expression:
- highly expressed in spleen > thymus, peripheral blood leukocytes, pancreas, placenta
- weakly expressed in lung, kidney, prostate, ovary & colon
General
serine/threonine kinase
Properties
SIZE: entity length = 716 aa
MW = 80 kD
COMPARTMENT: cytoplasm
STATE: active state
MOTIF: kinase domain
SITE: 9-315
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 15-23
ATP-binding site
NAME: ATP-binding site
SITE: 38-38
aspartate residue {D135}
Ser phosphorylation site {S172}
leucine zipper
SITE: 436-457
FOR-BINDING-VIA: leucine zipper
References
- UniProt :accession Q14164
- SeattleSNPs
http://pga.gs.washington.edu/data/ikbke/
- Peters RT et al
IKKepsilon is part of a novel PMA-inducible IkappaB kinase
complex.
Molecular Cell 5:513-22, 2000
PMID: 10882136
Databases & Figures
OMIM 605048
UniProt Q14164
Pfam PF00069
Entrez Gene 9641
Kegg hsa:9641
TNFR/IL1R1/CD28/TCR-CD3 -> NF kappa B