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elongator complex protein 1; ELP1; IkappaB kinase complex-associated protein; IKK complex-associated protein; p150 (IKBKAP, ELP1, IKAP, DYS)
Function:
- may act as a scaffold protein that may assemble active IkB kinase complex & MAP3K14 complex
- subunit of the RNA polymerase 2 elongator complex, thus may play a role in chromatin remodeling & acetylation of histones H3 & H4
- interacts preferentially with MAP3K14/NIK followed by IKK-alpha & IKK-beta
- associates with the C-terminal domain (CTD) of POLR2A
- interacts with ELP3
- phosphorylated
Structure: belongs to the ELP1/IKA1 family
Compartment: cytoplasm. nucleus
Pathology:
- defects in IKBKAP are the cause of familial dysautonomia (Riley-Day syndrome)
General
phosphoprotein
Properties
SIZE: entity length = 1332 aa
MW = 150 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S471}
Ser phosphorylation site {S867}
Ser phosphorylation site {S1171}
Ser phosphorylation site {S1174}
Database Correlations
OMIM correlations
MORBIDMAP 603722
UniProt O95163
Pfam PF04762
Entrez Gene 8518
References
- UniProt :accession O95163
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=IKBKAP
- Cohen L et al
IKAP is a scaffold protein of the IkappaB kinase complex.
Nature 395:292-6, 1998
PMID: 9751059
Component-of
IkB kinase complex