invasion-inhibitory protein 45; IGFBP2-binding protein (IIP45, MIIP)

Function: - inhibibits glioma cells invasion & down-regulates adhesion- & motility-associated genes such as NFKB2 & ICAM1 - exhibits opposing effects to IGFBP2 on cell invasion - interacts with IGFBP2 - isoform 2 is degraded by the ubiquitin-proteasome pathway Alternative splicing: named isoforms=2 Expression: - ubiquitous - isoform 1 is expressed in brain but underexpressed in glioma tissues, at protein level - up-regulated by IGFBP2 Pathology: - isoform 2 is not detected in normal organs, but is expressed in gliomas with increasing levels with glioma progression - on the contrary, at protein level, isoform 2 is not detected in gliomas, suggesting that this isoform is unstable in glioma cells

Properties

GENERAL: uncharacterized protein SIZE: entity length = 388 aa MW = 43 kD FORM: invasion-inhibitory protein 45 MOTIF: IGFBP2 interaction {239-282}

Database Correlations

OMIM 608772 UniProt Q5JXC2

References

UniProt :accession Q5JXC2