immunoglobulin-G3 (IgG3)

IgG3 is the most effective binder of complement among the subtypes of IgG (3+). Laboratory: - IgG3 in serum

Related

complement-fixing antibody IgG3 in serum

Properties

SIZE: MW = 150 kD COMPARTMENT: plasma SECRETED-BY: plasma cell SUBUNITS: Ig-gamma (2) MOTIF: Ig heavy chain variable region NAME: Ig heavy chain variable region heavy chain constant region-1 MOTIF: cysteine residue {CH1.SITE1} MODIFICATION: cysteine residue {CH1.SITE2} cysteine residue {CH1.SITE2} MODIFICATION: cysteine residue {CH1.SITE1} cysteine residue {C-TO-CH1} MODIFICATION: cysteine residue {C-TO-CL} hinge region MOTIF: cysteine residue {HINGE1} MODIFICATION: cysteine residue {HINGE1} cysteine residue {HINGE2} MODIFICATION: cysteine residue {HINGE2} heavy chain constant region-2 MOTIF: cysteine residue {CH2.SITE1} MODIFICATION: cysteine residue {CH2.SITE2} cysteine residue {CH2.SITE2} MODIFICATION: cysteine residue {CH2.SITE1} heavy chain constant region-3 MOTIF: cysteine residue {CH3.SITE1} MODIFICATION: cysteine residue {CH3.SITE2} cysteine residue {CH3.SITE2} MODIFICATION: cysteine residue {CH3.SITE1} immunoglobulin light chain (2) MOTIF: Ig light chain variable region NAME: Ig light chain variable region light chain constant region MOTIF: cysteine residue {CLSITE1} MODIFICATION: cysteine residue {CL.SITE2} cysteine residue {CL.SITE2} MODIFICATION: cysteine residue {CL.SITE1} cysteine residue {C-TO-CL} MODIFICATION: cysteine residue {C-TO-CH1}

References

Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998

Components

immunoglobulin gamma chain (Ig-gamma) immunoglobulin light chain