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immunoglobulin-G (IgG, Cuvitru)
humoral immunity
Subclasses: IgG1, IgG2, IgG3, IgG4.
IgG1 & IgG3 generally react with protein antigens.
IgG2 & IgG4 generally react with polysaccharide antigens.
Many healthy individuals do not have detectable amounts of IgG4.
Pharmacology:
- Cuvitru
Laboratory:
- IgG in tissue
- IgG in body fluid
- IgG in blood
- IgG in CSF
- IgG monoclonal in CSF
- IgG in peritoneal fluid
- IgG in serum
- IgG monoclonal in serum
- IgG in urine
Related
Fc gamma receptor
hypogammaglobulinemia; immunoglobulin deficiency
IgG Ag in skin
IgG in body fluid
IgG subclass deficiency
Specific
anti-thymocyte globulin (ATG)
Igg Parenteral
immunoglobulin-G1 (IgG1)
immunoglobulin-G2 (IgG2)
immunoglobulin-G3 (IgG3)
immunoglobulin-G4 (IgG4)
intravenous immunoglobulin (Baygam, Octagam)
General
immunoglobulin
Properties
SIZE: MW = 150 kD
COMPARTMENT: plasma
SECRETED-BY: plasma cell
SUBUNITS: Ig-gamma (2)
MOTIF: Ig heavy chain variable region
NAME: Ig heavy chain variable region
heavy chain constant region-1
MOTIF: cysteine residue {CH1.SITE1}
MODIFICATION: cysteine residue {CH1.SITE2}
cysteine residue {CH1.SITE2}
MODIFICATION: cysteine residue {CH1.SITE1}
cysteine residue {C-TO-CH1}
MODIFICATION: cysteine residue {C-TO-CL}
hinge region
MOTIF: cysteine residue {HINGE1}
MODIFICATION: cysteine residue {HINGE1}
cysteine residue {HINGE2}
MODIFICATION: cysteine residue {HINGE2}
heavy chain constant region-2
MOTIF: cysteine residue {CH2.SITE1}
MODIFICATION: cysteine residue {CH2.SITE2}
cysteine residue {CH2.SITE2}
MODIFICATION: cysteine residue {CH2.SITE1}
heavy chain constant region-3
MOTIF: cysteine residue {CH3.SITE1}
MODIFICATION: cysteine residue {CH3.SITE2}
cysteine residue {CH3.SITE2}
MODIFICATION: cysteine residue {CH3.SITE1}
immunoglobulin light chain (2)
MOTIF: Ig light chain variable region
NAME: Ig light chain variable region
light chain constant region
MOTIF: cysteine residue {CLSITE1}
MODIFICATION: cysteine residue {CL.SITE2}
cysteine residue {CL.SITE2}
MODIFICATION: cysteine residue {CL.SITE1}
cysteine residue {C-TO-CL}
MODIFICATION: cysteine residue {C-TO-CH1}
MISC-INFO: CONCENTRATION 0.7-1.5 G/DL
References
Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
Component-of
molecular complex
Components
immunoglobulin gamma chain (Ig-gamma)
immunoglobulin light chain