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insulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; prostacyclin-stimulating factor; tumor-derived adhesion factor; TAF (IGFBP7, MAC25, PSF)
Function:
1) binds IGF1 & IGF2 with low affinity
2) stimulates prostacyclin (PGI2) production
3) stimulates cell adhesion
3) may interact with VPS24/CHMP
Structure:
- N-glycosylated
- contains 1 Ig-like C2-type domain
- contains 1 IGFBP N-terminal domain
- contains 1 Kazal-like domain
Compartment: secreted
RNA editing:
- modified_positions = 78, 95
- partially edited
- in the brain, position 78 is edited at about 55% & position 95 at about 31%
Pathology:
- defects in IGFBP7 are the cause of RAMSVPS, retinal arterial macroaneurysm with supravalvular pulmonic stenosis
General
glycoprotein
insulin-like growth factor [IGF]-binding protein
Properties
SIZE: entity length = 282 aa
MW = 29 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
IGFBP N-terminal {28-106}
Kazal-type serine protease inhibitor domain {105-158}
MOTIF: cysteine residue {X+0}
MODIFICATION: cysteine residue {X+X4}
cysteine residue {X+X1}
MODIFICATION: cysteine residue {X+X3}
cysteine residue {X+X2}
MODIFICATION: cysteine residue {X+X5}
cysteine residue {X+X3}
MODIFICATION: cysteine residue {X+X1}
cysteine residue {X+X4}
MODIFICATION: cysteine residue {X+0}
cysteine residue {X+X5}
MODIFICATION: cysteine residue {X+X2}
FOR-BINDING-OF: serine protease
immunoglobulin superfamily domain {160-264}
MOTIF: N-glycosylation site {N171}
cysteine residue {C181}
MODIFICATION: cysteine residue {C248}
cysteine residue {C248}
MODIFICATION: cysteine residue {C181}
SECRETED-BY: hepatocyte
smooth muscle
Database Correlations
OMIM correlations
UniProt Q16270
PFAM correlations
Entrez Gene 3490
Kegg hsa:3490
References
- UniProt :accession Q16270
- NIEHS-SNPs
http://egp.gs.washington.edu/data/igfbp7/