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insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5 (IGFBP5 IBP5)
Function:
- IGF-binding proteins prolong the half-life of the IGFs
- they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
- they alter the interaction of IGFs with their cell surface receptors
Structure:
- contains 1 IGFBP N-terminal domain
- contains 1 thyroglobulin type-1 domain
Compartment: secreted
Expression:
- expressed in osteosarcoma
- expressed at lower levels in liver, kidney & brain
General
glycoprotein
insulin-like growth factor [IGF]-binding protein
Properties
SIZE: entity length = 272 aa
MW = 31 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
IGFBP N-terminal {23-103}
Thr glycosylation site {T172}
Thyroglobulin type-1 {189-263}
MOTIF: cysteine residue {C192}
MODIFICATION: cysteine residue {C219}
cysteine residue {C219}
MODIFICATION: cysteine residue {C192}
cysteine residue {C230}
MODIFICATION: cysteine residue {C241}
cysteine residue {C241}
MODIFICATION: cysteine residue {C230}
cysteine residue {C243}
MODIFICATION: cysteine residue {C263}
cysteine residue {C263}
MODIFICATION: cysteine residue {C243}
SECRETED-BY: hepatocyte
smooth muscle
Database Correlations
OMIM 146734
UniProt P24593
PFAM correlations
Entrez Gene 3488
Kegg hsa:3488
References
- UniProt :accession P24593
- NIEHS-SNPs
http://egp.gs.washington.edu/data/igfbp5/
- Entrez Gene :accession 3488