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insulin-like growth factor [IGF]-2 receptor (CD222, somatomedin MSA receptor, cation-independent mannose-6-phosphate receptor, MPR 300, CI-MPR, M6PR, MPRI, IGF2R)
Function:
- binds IGF2
- as receptor for IGF2, may play a role in consolidation & reconsolidation of memories
- transport of phosphorylated lysosomal enzymes from the Golgi & the cell surface to lysosomes
- lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi & the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex
- positive regulator of T-cell coactivation by binding DPP4
- also binds GGA1, GGA2 & GGA3
Structure:
- contains 15 repeating units of approximately 147 AA
- the most highly conserved region within the repeat consists of a stretch of 13 AA that contains Cys at both ends
- belongs to the MRL1/IGF2R family
- contains 1 fibronectin type-2 domain
Compartment:
- lysosome membrane
- colocalizes with DPP4 in internalized cytoplasmic vesicles adjacent to cell surface
Interactions
molecular events
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 2491 aa
MW = 274 kD
COMPARTMENT: lysosome
STATE: active state
MOTIF: signal sequence {1-40}
consensus repeat {40-189}
MOTIF: N-glycosylation site {N112}
consensus repeat {190-344}
consensus repeat {345-489}
MOTIF: N-glycosylation site {N400}
N-glycosylation site {N435}
consensus repeat {490-643}
MOTIF: N-glycosylation site {N543}
N-glycosylation site {N581}
N-glycosylation site {N626}
consensus repeat {644-783}
MOTIF: N-glycosylation site {N747}
consensus repeat {784-950}
MOTIF: N-glycosylation site {N871}
consensus repeat {951-1099}
MOTIF: N-glycosylation site {N951}
N-glycosylation site {N957}
consensus repeat {1100-1243}
MOTIF: N-glycosylation site {N1164}
consensus repeat {1244-1384}
MOTIF: N-glycosylation site {N1246}
N-glycosylation site {N1312}
consensus repeat {1385-1532}
consensus repeat {1533-1666}
MOTIF: N-glycosylation site {N1656}
consensus repeat {1667-1820}
MOTIF: N-glycosylation site {N1757}
N-glycosylation site {N1816}
consensus repeat {1821-2008}
MOTIF: fibronectin type II domain or F2 module
SITE: 1898-1944
FOR-BINDING-OF: collagen
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*3}
cysteine residue {*2}
MODIFICATION: cysteine residue {*4}
cysteine residue {*3}
MODIFICATION: cysteine residue {*1}
cysteine residue {*4}
MODIFICATION: cysteine residue {*2}
cysteine residue {C1903}
MODIFICATION: cysteine residue {C1927}
cysteine residue {C1917}
MODIFICATION: cysteine residue {C1942}
cysteine residue {C1927}
MODIFICATION: cysteine residue {C1903}
cysteine residue {C1942}
MODIFICATION: cysteine residue {C1917}
consensus repeat {2009-2137}
MOTIF: N-glycosylation site {N2085}
N-glycosylation site {N2136}
consensus repeat {2165-2289}
transmembrane domain {2305-2327}
Ser phosphorylation site {S2409}
Ser phosphorylation site {S2479}
Ser phosphorylation site {S2484}
Database Correlations
OMIM 147280
MORBIDMAP 147280
UniProt P11717
PFAM correlations
Kegg hsa:3482
References
- Nishibe S et al
Selectivity of phospholipase C phosphorylation by the
epidermal growth factor receptor, the insulin receptor,
and their cytoplasmic domains.
Proc Natl Acad Sci U S A. 1990 Jan;87(1):424-8.
Erratum in: Proc Natl Acad Sci U S A 1990 Apr;87(8):3253.
Kim JJ [corrected to Kim JW].
PMID: 2153302
- Cross M, Dexter TM.
Growth factors in development, transformation, and tumorigenesis.
Cell. 1991 Jan 25;64(2):271-80. Review.
PMID: 1988148
- Nishimoto I, Murayama Y, Katada T, Ui M, Ogata E.
Possible direct linkage of insulin-like growth factor-II
receptor with guanine nucleotide-binding proteins.
J Biol Chem. 1989 Aug 25;264(24):14029-38.
PMID: 2547780
- UniProt :accession P11717
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/IGF2RID380.html