insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3, IGF-2 mRNA-binding protein 3, IMP-3, KH domain-containing protein overexpressed in cancer, hKOC, VICKZ family member 3, IGF2BP3, IMP3, KOC1, VICKZ3)

Function: 1) RNA-binding protein 2) regulator of mRNA translation & stability 3) binds to the 5'-UTR of IGF2 mRNA 4) binds to sequences in the 3'-UTR of CD44 mRNA Structure: - homodimer & multimer - belongs to the RRM IMP/VICKZ family - contains 4 KH domains - contains 2 RRM repeats (RNA recognition motif) Compartment: - nucleus, cytoplasm - found in lamellipodia of leading edge, in perinuclear region, & beneath the plasma membrane - subcytoplasmic localization is cell specific & regulated by cell contact & growth - localized at connecting piece & tail of spermatozoa - colocalized with CD44 mRNA in RNP granules Alternative splicing: named isoforms=3 Expression: - expressed in fetal liver, lung, kidney, thymus, placenta, follicles of ovary & gonocytes of testis - expressed in growing oocytes, spermatogonia & semen - ubiquitously during fetal development at 8 & 14 weeks of gestation Pathology: - expressed in cervical cancer (adenocarcinoma) - expressed in testicular cancer - expressed in pancreatic cancer - expressed in renal-cell carcinomas - expressed in ovarian cancer - autoantibodies against IGF2BP3 are detected in sera from some patients with a variety of carcinomas

Properties

SIZE: MW = 64 kD entity length = 579 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 2-75 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 81-156 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif KH domain SITE: 195-260 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 276-343 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 405-470 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 487-553 FOR-BINDING-OF: ribonucleic acid

Database Correlations

OMIM 608259 UniProt O00425 PFAM correlations

References

UniProt :accession O00425