insulin-like growth factor 2 mRNA-binding protein 2 (IGF-2 mRNA-binding protein 2, IMP-2, hepatocellular carcinoma autoantigen p62, IGF2BP2, IMP2)

Function: 1) binds to the 5' untranslated region of IGF2 mRNAs - binding is isoform-specific 2) may regulate translation of target mRNAs Structure: - contains 4 KH domains - contains 2 RRM domains (RNA recognition motif) Compartment: cytoplasm Expression: - expressed in adult heart, placenta, skeletal muscle, pancreas, fetal liver Pathology: - autoantibodies against IGF2BP2 are detected in sera from some patients with hepatocellular carcinoma

Properties

SIZE: MW = 62 kD entity length = 556 aa COMPARTMENT: cytoplasm MOTIF: RNP motif NAME: RNP motif SITE: 3-76 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 82-157 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif KH domain SITE: 193-258 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 274-341 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 384-449 FOR-BINDING-OF: ribonucleic acid KH domain SITE: 466-532 FOR-BINDING-OF: ribonucleic acid

Database Correlations

OMIM 608289 MORBIDMAP 608289 UniProt Q9Y6M1 PFAM correlations

References

UniProt :accession Q9Y6M1